The drug-free approach breaks apart the neurotoxic amyloid plaques that result in memory loss and cognitive decline.
It could fundamentally change the understanding of how to treat Alzheimer's,researcher director Professor Jurgen Gotz said.
"The ultrasound waves oscillate tremendously quickly,activating microglial cells that digest and remove the amyloid plaques that destroy brain synapses,"he said.
"This treatment restored memory function to the same level of normal healthy mice."
Premier Annastacia Palaszczuk described the work as revolutionary.
"This is the first stage and the next stage will be research on other animals,"she said.
"We could be now one step closer to finding a treatment for this disease."