ABC'sFour Corners program on Monday detailed that incident and other cases of children enduring lengthy periods in adult holding cells because the state's youth detention centres are full.
"That is a serious allegation and that matter is currently under a full investigation,"Ms Palaszczuk told state parliament.
"I spoke to the director-general this morning.
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"She has advised me that the matters that were raised on the Four Corners program,that the (Child Safety Minister Di Farmer) was not aware of and that I was not aware of,will be fully investigated."
Her office later clarified those remarks,and said the Department of Premier and Cabinet's Acting Director General,Rachel Hunter,has held meetings across government since the allegations were raised by Public Guardian Natalie Siegel- Brown,and briefed the premier.
It says the department was advised by Queensland Police that the young girl was in an adjacent cell to the men,that there was never any ability for personal or physical interaction and that she was moved when alternative areas were cleared.